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Methyltransferases for Epigenetics

New England Biolabs offers DNA methyltransferases and related reagents for epigenetics research.

DNA methyltransferase enzymes modify DNA by adding a methyl group to either cytosines or adenines depending on the specificity of the enzyme. Our methyltransferases, S-adenosylmethionine (SAM) cofactor, and 5-methyl-dCTP nucleotides are useful in many applications for basic research, epigenetic drug discovery, and the development of molecular diagnostics.

  • Generating positive controls with genomic DNA for methylation-specific PCR or sequencing
  • Methylated CpG gene expression studies
  • DNA labeling with SAM analogs to modify, or identify, methyltransferase substrates
  • Generating methylated DNA probes for methyltransferase activity assays
  • Chromatin accessibility studies
  • Nucleosome and chromatin associated protein (CAP) footprinting

5mC methylated cytosine

DNA methyltransferases can modify cytosine for assays or diagnostics


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Methyltransferases for Epigenetics
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5-methyl-dCTP

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AluI Methyltransferase

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BamHI Methyltransferase

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CpG Methyltransferase (M.SssI)

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dam Methyltransferase

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EcoGII Methyltransferase

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EcoRI Methyltransferase

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GpC Methyltransferase (M.CviPI)

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HaeIII Methyltransferase

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Hhal Methyltransferase

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HpaII Methyltransferase

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MspI Methyltransferase

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S-adenosylmethionine (SAM)

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TaqI Methyltransferase


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Legal Information

Products and content are covered by one or more patents, trademarks and/or copyrights owned or controlled by New England Biolabs, Inc (NEB). The use of trademark symbols does not necessarily indicate that the name is trademarked in the country where it is being read; it indicates where the content was originally developed. All other trademarks are the property of their respective owners. The use of this product may require the buyer to obtain additional third-party intellectual property rights for certain applications. For more information, please email busdev@neb.com.

This product is intended for research purposes only. This product is not intended to be used for therapeutic or diagnostic purposes in humans or animals.